Canine Fucosidosis | Animal Genetics


News Item

Equine Performance Testing
Animal Genetics will soon be offering an equine performance panel. We hope to have more information available soon.

News Item

March 5th-8th, 2015
Animal Genetics Inc. has been invited to attend Crufts dog show from 5th-8th of March 2015 in Birmingham England. Processing of samples submitted during this time may be delayed a few days. Please accept our apologies as we will be back on schedule as soon as we can.

News Item

September, 2014
New test available for dogs. Please see Collie Eye Anomaly (CEA)

News Item

March, 2014
Animal Genetics purchases an additional genetic analyzer (ABI3130xl) to handle increased demand and improve service.

Canine Fucosidosis (CF)


Canine fucosidosis is an autosomal recessive disorder found in English Springer Spaniels that affects the dog's ability to produce the enzyme alpha-fucosidase. This enzyme deficiency prohibits the normal breakdown and metabolism of complex polysaccharides from within the cells. Instead, these compounds build up in the cells and diminish the cell's ability to function properly. Accumulation of these compounds in the brain and nervous systems gives rise to the outward signs of the disease.


The disorder affects dogs between 18 months and 4 years of age. Clinically, the disease is characterised by a decrease in central nervous system functions. Signs can include loss of learned behavior, change in temperament, blindness, loss of balance, deafness and weight loss. From the onset of symptoms, the disease will progress quickly and is fatal.

Because fucosidosis is a recessive disorder, the dog must have two copies of the defective gene (one from each parent) to suffer from the disease. A dog that carries one copy of the mutation does not exhibit any symptoms. However, they can still pass on a copy of the mutation to any offspring. If two carrier dogs produce a litter of puppies, each pup has a 25% chance of being affected by Fucosidosis.

Sample Type:

Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at Canine Test Now.

Test Is Relevant to the Following Breeds:

English Springer Spaniel


Animal Genetics offers DNA testing for canine fucosidosis. The genetic test verifies the presence of the recessive fucosidosis mutation and presents results as one of the following:

FC/FC Affected The dog carries two copies of the mutant gene and is homozygous for fucosidosis. The dog is affected by canine fucosidosis and will always pass a copy of the mutation to its offspring.
FC/n Carrier Both the normal and mutant copies of the gene detected. Dog is a carrier for the canine fucosidosis mutation and can pass on a copy of the defective gene to its offspring.
n/n Clear Dog tested negative for the fucosidosis mutation and will not pass on the defective gene to its offspring.